A trans-kingdom antimicrobial peptide targeting cystic fibrosis pathogens
نویسندگان
چکیده
منابع مشابه
Antimicrobial peptide therapeutics for cystic fibrosis.
Greater than 90% of lung infections in cystic fibrosis (CF) patients are caused by Pseudomonas aeruginosa, and the majority of these patients subsequently die from lung damage. Current therapies are either targeted at reducing obstruction, reducing inflammation, or reducing infection. To identify potential therapeutic agents for the CF lung, 150 antimicrobial peptides consisting of three distin...
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S20 Figure 1 . Conclusion In vitro MreB is an attractive new target for novel antimicrobials. Further analysis of current observations and additional phenotypic analysis will be required to dissect the nature of Q22induced changes. Work supported by Newcastle-Upon-Tyne Hospitals Special Trustees and Italian CF Research Foundation (FFC). S21 IDENTIFICATION OF PSEUDOMONAS AERUGINOSA INFECTION VIA...
متن کاملEmerging cystic fibrosis pathogens: incidence and antimicrobial resistance.
We examined the frequency of isolation and the antimicrobial resistance of Burkholderia cepacia complex, Stenotrophomonas maltophilia and Achromobacter xylosoxidans in cystic fibrosis patients from 2000 to 2004. Strains susceptibility to tobramycin, piperacillin/tazobactam, imipenem, gentamicin, ciprofloxacin and ceftazidime was determined by disc diffusion assay. B. cepacia complex showed a ve...
متن کاملPrevalence of Cystic Fibrosis Trans-membrane Conductance Regulator Gene common mutations in children with cystic fibrosis in Isfahan, Iran
Background: Cystic fibrosis (CF) is the most common lethal genetic disorder of Cystic Fibrosis Trans-membrane Conductance (CFTR) Regulator gene mutations. We aimed to investigate common mutations in CF patients and to assess its possible relationship with clinical presentations. Materials and Methods: This cross sectional study was conducted on 36 CF patients who were referred to a tertiary ped...
متن کاملTargeting inflammation in cystic fibrosis.
disease, such as n –3 polyunsaturated fatty acids, receptor antagonists of the cysteinyl leukotrienes, macrolides, N acetylcysteine, and -1 antitrypsin have shown clinical efficacy or potential for clinical use, but to date no ideal anti-inflammatory agent for CF lung disease has been found [10] . Because of the notable side effects of broad-spectrum anti-inflammatory drugs, a more targeted app...
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ژورنال
عنوان ژورنال: Journal of Genetic Syndromes & Gene Therapy
سال: 2016
ISSN: 2157-7412
DOI: 10.4172/2157-7412.1000308